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Aitor López Peláez
Nichita Stopler, Shirly. De la Fuente. No incluye Repetición de bebidas Otras bebidas cervezas, refrescos…. Lopez Guajardo, Aitor lopez pelaez reus.
Federal government websites often end in. The site is secure. Madrid, Madrid, Spain. The significant impact of COVID worldwide has made it necessary to develop tools to identify patients at high risk of severe disease and death.
The nomogram uses five variables measured on arrival to the emergency department ED : age, sex, oxygen saturation, C-reactive protein level, and neutrophil-to-platelet ratio. The cohort was divided into three time periods: T1 from February 1 to June 10, first wave , T2 from June 11 to December 31, second wave, pre-vaccination period , and T3 from January 1 to December 5, vaccination period.
Clinical and laboratory data from 22, patients were analyzed: 15, This tool showed good predictive ability in successive disease waves. The online version contains supplementary material available at The COVID pandemic, a disease caused by severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 , has had a huge impact on healthcare systems worldwide and resulted in more than million known infections and well over 6.
A highly accurate tool for predicting the clinical course of this disease could be very useful for risk stratification, clinical decision-making, and ultimately for reducing mortality.
Applying the nomogram to the validation cohort, the area under the receiver operating characteristics curve AUROC was 0. Over 24, patients over 18 years of age were included. However, since the start of the pandemic, multiple factors have changed the course of disease because the clinical management [ 20 ], available resources, and treatments indicated have evolved since the beginning of the pandemic [ 19 , 21 ]. Patients included in open-label clinical trials could be included in the registry, provided that all information about treatment was available.
An online electronic data capture system DCS was developed, which included a database manager along with procedures for the verification of data and contrasting of information against the original medical record to ensure the best possible quality of data collection. Patient identifiable data were dissociated and pseudonymized. The first time period T1 was February 1 to June 10, first wave. The cut-off point of June 10, was selected for two reasons: first, because it was the date that the last patient was included in the original validation model for the RIM Score-COVID and second, because it is the approximate date of transition between the first and second waves of the COVID pandemic in Spain.
The second time period T2 was from June 11 to December 31, second wave and pre-vaccination period. The second cut-off point of December 31, was selected for two reasons: first, because vaccination in Spain began soon before on December 26, and second, because it is the approximate date of transition between the third and fourth waves in Spain. The third time period T3 was from January 1 to December 5, T3 is the vaccination period. The initial nomogram was developed in a cohort of 2, patients with COVID requiring hospital admission, of which 1, The patients were randomly divided into training and validation cohorts; applying the nomogram to the latter cohort, the area under the receiver operating characteristics curve AUROC was 0.
The nomogram developed is shown in Fig. For several weeks in the first wave, COVID was diagnosed based solely on clinical and radiological criteria. Nomograms of the NPR model. Data were expressed as medians interquartile range for continuous variables or as numbers and percentages for categorical variables. The normality of the distribution was assessed using the Kolmogorov—Smirnov test. Pearson's Chi-square test was performed to compare categorical variables between groups.
The Python package "scikit-learn" 1. Confidence intervals were estimated through bootstrapping tenfold cross-validation resampling, also calculated with scikit-learn 1. The study was conducted in accordance with ethical principles and was conducted pursuant to good clinical practice standards and the principles of the latest versions of the Declaration of Helsinki and the Oviedo Convention All patients gave informed consent. All data collected, processed, and analyzed in this work were anonymized and used only for the purposes of this project.
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